Melanoma-in-situ of the Chin
A middle-age man with previous melanoma-in-situ of the back presents with new chin lesion biopsied as melanoma-in-situ on a deep shave biopsy. Subsequent surgical excision with 2 mm margins revealed...
View ArticleNew Melanoma Staining: SOX10 and MiTF
S-100, tyrosinase, Melan A, and HMB 45 have been the workhorses of melanocyte histopathology. A new immunohistochemical stain, SOX10, has recently been shown to be a useful marker in the diagnosis of...
View ArticleMohs excision of Melanoma in situ and Melanoma
We are excited to introduce our new feature – Journal Club. This month we are discussing Mohs excision of melanoma. Please read the Journal Club Articles for this month. Melanoma immunohistochemistry...
View ArticleMelanoma and Melanoma In-Situ Mohs Rapid Staining
Mohs micrographic surgery has emerged as a standard of care for excision of melanoma and melanoma in situ. Local control rates are as high as 97% at 5 years for both melanoma and melanoma in situ....
View ArticleLeft Cheek Recurrent Melanoma In-Situ
Thirty something year old with recurrent melanoma in situ of the left cheek following excision 2 years ago with clear margins. The recurrence is a small pigmented area on one end of the scar....
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Melafind and the FDA Bureaucrats
Melafind is a highly anticipated device that had just received FDA approval. It is a noninvasive handheld device that evaluates suspicious pigmented lesions for need to biopsy. Melafind System...
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STUMP and MelTUMP
Ambiguous melanocytic lesions – those with histopathologic findings without a diagnostic consensus – are divided into thin and thick tumors. Thin lesions appear as dysplastic nevi and have a potential...
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DNA Molecular Testing and Personalized Medicine – Part 2
Another genetic molecular technology that has evolved tremendously is real time polymerase chain reaction (PCR). When accompanied by reverse transcription prior to PCR (RT-PCR), it has also allowed...
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